Hans Clevers

Hubrecht Institute/ UMC Utrecht

Clevers is group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and professor of Molecular Genetics at the University Medical Center Utrecht and Utrecht University. He is also Director Research of the Princess Máxima Center for Pediatric Oncology and Oncode Investigator. His research is rooted in the Wnt signaling pathway. The Clevers group studies the biology of Wnt signaling in tissue turnover and in cancer. They developed a groundbreaking technology to grow Wnt-dependent stem cells into ever-expanding epithelial organoids. These organoids recapitulate many aspects of their tissue of origin and allow the study of a multitude of physiological and pathological processes. Patient-derived organoids hold promise to predict drug response in a personalized fashion and open up new avenues for regenerative medicine and, in combination with genome editing technology, for gene therapy.
Clevers has been honoured with many (inter)national prizes and awards, including the prestigious Spinoza Award of NWO. Clevers was elected as the president of the Royal Netherlands Academy of Arts and Sciences (KNAW) and is Knight in the order of the Netherlands’ Lion.